Coupling of renal sodium and calcium transport: a modeling analysis of transporter inhibition and sex differences
Shervin Hakimi, Pritha Dutta, Anita T. Layton
Abstract
The kidney plays an important role in the maintenance of whole body Ca 2+ balance by regulating Ca 2+ reabsorption and excretion. This computational modeling study provides insights into how Ca 2+ transport along the nephron is coupled to Na + . Model results indicated that along the proximal tubule and thick ascending limb, Ca 2+ and Na + transport occur in parallel, but those processes were dissociated in the distal convoluted tubule. Simulations also revealed sex-specific responses to different pharmacological manipulations.
Topics & Concepts
NephronReabsorptionParacellular transportConvoluted tubuleDistal convoluted tubuleInternal medicineChemistryEndocrinologyKidneyTranscellularTubuleIon transporterRenal physiologyTubuloglomerular feedbackTubular fluidBiophysicsBiologyMedicineBiochemistryPermeability (electromagnetism)MembraneIon Transport and Channel RegulationRenal function and acid-base balanceElectrolyte and hormonal disorders