A single molecular descriptor to predict solution behavior of therapeutic antibodies
Jonathan S. Kingsbury, Amandeep Saini, Sarah M. Auclair, Li Fu, Michaela M. Lantz, Kevin T. Halloran, Cesar Calero‐Rubio, Walter Schwenger, Christian Airiau, Jifeng Zhang, Yatin R. Gokarn
Abstract
. We also show that well-behaved mAbs, a substantial subset of which bear high positive charge and pI, present no disadvantages with respect to pharmacokinetics in humans. Here, we provide a systematic framework with quantitative thresholds for selecting well-behaved therapeutic mAbs during drug discovery.
Topics & Concepts
Selection (genetic algorithm)AntibodyComputational biologyBiological systemComputer scienceChemistryBiologyArtificial intelligenceImmunologyMonoclonal and Polyclonal Antibodies ResearchProtein purification and stabilityViral Infectious Diseases and Gene Expression in Insects