Iron deficiency exacerbates aortic medial degeneration by inducing excessive mitochondrial fission
Xiaohan Zhong, Qi Wu, Zhiwei Wang, Min Zhang, Sihao Zheng, Feng Shi, Yuanyang Chen, Yanjia Che, Shun Yuan, Kai Xing
Abstract
mice with subcutaneous AngII osmotic pumps. ID facilitated the formation of mitochondria-associated endoplasmic reticulum membranes (MAMs), which triggered excessive mitochondrial fission, induced the phenotypic transformation of VSMCs, and ultimately accelerated the progression of AMD. Furthermore, the present study indicated that an inhibitor of Drp1 could partially reverse this process. Maintaining iron balance in the human body may prevent the development of AAD.
Topics & Concepts
Mitochondrial fissionFIS1Endoplasmic reticulumMitochondrionCell biologyDownregulation and upregulationPhenotypeApoptosisVascular smooth musclePathogenesisBiologymitochondrial fusionEndocrinologyBiochemistryImmunologyGeneMitochondrial DNASmooth muscleAortic Disease and Treatment ApproachesMitochondrial Function and PathologyAortic aneurysm repair treatments