Autophagy is required during high MUC2 mucin biosynthesis in colonic goblet cells to contend metabolic stress
Sameer K. Tiwari, Sharmin Begum, France Moreau, Hayley Gorman, Kris Chadee
Abstract
It is unclear how colonic goblet cells survive by producing high output MUC2 mucin that triggers endoplasmic stress by misfolded MUC2 proteins. To cope with metabolic stress, we interrogated if autophagy played an essential role in regulating cellular homeostasis. Indeed, high MUC2 mucin biosynthesis dysregulated autophagy processes that was regulated by IL-22 to maintain gut barrier innate host defenses.
Topics & Concepts
AutophagyMucinCell biologyMucin 2Endoplasmic reticulumHomeostasisUnfolded protein responseBiologyBiosynthesisChemistryBiochemistryEnzymeGeneGene expressionApoptosisAutophagy in Disease and TherapyGlycosylation and Glycoproteins ResearchGalectins and Cancer Biology