TCRαβ<sup>+</sup>NK1.1<sup>-</sup>CD4<sup>-</sup>CD8<sup>-</sup> double-negative T cells inhibit central and peripheral inflammation and ameliorate ischemic stroke in mice
Dan Tian, Yuhualei Pan, Yushang Zhao, Huan Wang, Yue Tian, Lu Yang, Wen Shi, Chengjie Zhang, Yanbing Zhu, Yongbo Zhang, Songlin Wang, Dong Zhang
Abstract
DNT cell treatment renders the comprehensive anti-inflammatory roles in specific phases of ischemic stroke. Our study suggests that the adoptive transfer of regulatory DNT cells may be a potential cell-based therapy for ischemic stroke.
Topics & Concepts
Immune systemAdoptive cell transferCD8InflammationMedicineStroke (engine)T cellImmunologyFlow cytometryEngineeringMechanical engineeringNeuroinflammation and Neurodegeneration MechanismsImmune cells in cancerImmune Cell Function and Interaction