Optimization of linear and cyclic peptide inhibitors of KEAP1-NRF2 protein-protein interaction
Stefania Colarusso, Daniele De Simone, Tommaso Frattarelli, Matteo Andreini, Mauro Cerretani, Antonino Missineo, Daniele Moretti, Sara Tambone, Georg Kempf, Martin Augustin, Stefan Steinbacher, Ignacio Muñoz-Sanjuán, Larry Park, Vincenzo Summa, Licia Tomei, Alberto Bresciani, Celia Dominguez, Leticia Toledo‐Sherman, Elisabetta Bianchi
Topics & Concepts
ChemistryCyclic peptidePeptideCell permeabilityProtein–protein interactionTranscription factorAmino acidComputational biologyDocking (animal)Small moleculeKEAP1Rational designBiochemistryCombinatorial chemistryBiophysicsNanotechnologyGeneBiologyMaterials scienceMedicineNursingGenomics, phytochemicals, and oxidative stressCoenzyme Q10 studies and effectsSynthesis and Biological Evaluation