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Pharmacokinetic Models Scaled Up from Humanized Liver Mouse Data Can Account for Drug Monitoring Results of Atomoxetine and Its 4-Hydroxylated and N-Demethylated Metabolites in Pediatric Patients Genotyped for Cytochrome P450 2D6

Makiko Shimizu, Shotaro Uehara, Katsuhiro Ohyama, Haruka Nishimura, Yoïchi Tanaka, Yoshiro Saito, Hiroshi Suemizu, Sayaka Yoshida, Hiroshi Yamazaki

2023Drug Metabolism and Disposition11 citationsDOIOpen Access PDF

Topics & Concepts

AtomoxetineCYP2D6Physiologically based pharmacokinetic modellingPharmacokineticsPharmacologyParoxetineCytochrome P450Atomoxetine hydrochlorideAdverse effectMetaboliteDrugTherapeutic drug monitoringMedicineAttention deficit hyperactivity disorderInternal medicineMethylphenidateMetabolismPsychiatrySerotoninReceptorPharmacogenetics and Drug MetabolismPharmacological Effects and Toxicity StudiesTreatment of Major Depression
Pharmacokinetic Models Scaled Up from Humanized Liver Mouse Data Can Account for Drug Monitoring Results of Atomoxetine and Its 4-Hydroxylated and N-Demethylated Metabolites in Pediatric Patients Genotyped for Cytochrome P450 2D6 | Litcius