FGF21 prevents low-protein diet-induced renal inflammation in aged mice
Han Fang, Sujoy Ghosh, Landon C. Sims, Kirsten P. Stone, Cristal M. Hill, Denisha Spires, Daria V. Ilatovskaya, Christopher D. Morrison, Thomas W. Gettys, Krisztián Stadler
Abstract
Long-term protein restriction is not advantageous for an otherwise healthy, aging kidney, as it facilitates the development of renal tubular injury and inflammatory cell infiltration. We provide evidence using FGF21 knockout animals that FGF21 is essential to counteract the renal injury and inflammation during aging on a low-protein diet.
Topics & Concepts
InflammationLow-protein dietMedicineInternal medicineEndocrinologyBiologyFibroblast Growth Factor ResearchKruppel-like factors researchEpigenetics and DNA Methylation