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A hydrogen-driven biocatalytic approach to recycling synthetic analogues of NAD(P)H

Holly A. Reeve, Jake H. Nicholson, Farieha Altaf, Thomas H. Lonsdale, Janina Preissler, Lars Lauterbach, Oliver Lenz, Silke Leimkühler, Frank Hollmann, Caroline E. Paul, Kylie A. Vincent

2022Chemical Communications19 citationsDOIOpen Access PDF

Abstract

Soluble hydrogenase enables atom efficient, H 2 -driven, recycling of synthetic nicotinamide cofactors.

Topics & Concepts

CofactorNAD+ kinaseBiocatalysisNicotinamideChemistryHydrogenaseCombinatorial chemistryReductaseStereochemistryEnzymeBiochemistryCatalysisReaction mechanismEnzyme Catalysis and ImmobilizationMetalloenzymes and iron-sulfur proteinsBiochemical and Molecular Research
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