Chronic cold exposure induces autophagy to promote fatty acid oxidation, mitochondrial turnover, and thermogenesis in brown adipose tissue
Winifred W. Yau, Kiraely A. Wong, Jin Zhou, Nivetha Kanakaram Thimmukonda, Yajun Wu, Boon‐Huat Bay, Brijesh Kumar Singh, Paul M. Yen
Abstract
KO mice were unable to maintain body temperature after chronic cold exposure and displayed deranged mitochondrial morphology and reactive oxygen species damage in their BAT. Our findings demonstrate the critical role of autophagy in adaptive thermogenesis, fatty acid metabolism, and mitochondrial function in BAT during chronic cold exposure.
Topics & Concepts
AutophagyThermogenesisBrown adipose tissueMitochondrionBeta oxidationAdipose tissueChemistryCell biologyBiochemistryFatty acidBiologyApoptosisAdipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and Adiposity