Synthesis and application of novel P-chiral monophosphorus ligands
Xiaoxiao Xie, Sanliang Li, Qiaoyu Chen, Hao Guo, Junfeng Yang, Junliang Zhang
Abstract
A series of novel P-stereogenic monophosphorus ligands (Xie-phos) were synthesized via the hydrophosphinylation of alkynes with secondary phosphine oxides by palladium catalysis and the following base mediated cyclization.
Topics & Concepts
StereocenterChemistryPhosphinePalladiumPhosCatalysisCombinatorial chemistryBase (topology)StereochemistryMedicinal chemistryEnantioselective synthesisOrganic chemistryBiochemistryMathematical analysisMathematicsAsymmetric Hydrogenation and CatalysisAsymmetric Synthesis and CatalysisChemical Synthesis and Analysis