PD-1 blockade and vaccination provide therapeutic benefit against SIV by inducing broad and functional CD8 <sup>+</sup> T cells in lymphoid tissue
Sheikh Abdul Rahman, Bhrugu Yagnik, Alexander P. R. Bally, Kristen N. Morrow, Shelly Wang, Thomas H. Vanderford, Gordon J. Freeman, Rafi Ahmed, Rama Rao Amara
Abstract
T cells to BCF and decreasing viral reservoirs in lymphoid tissue. This work has potential implications for the development of curative HIV strategies.
Topics & Concepts
BlockadeVaccinationCD8ImmunityLymphatic systemImmunologyVirologySimian immunodeficiency virusBiologyCytotoxic T cellImmune systemReceptorGeneticsIn vitroImmune Cell Function and InteractionHIV Research and TreatmentCytomegalovirus and herpesvirus research