Design, synthesis and biological evaluation of novel hybrids targeting mTOR and HDACs for potential treatment of hepatocellular carcinoma
Shiyang Zhai, Huimin Zhang, Rui Chen, Jiangxia Wu, Daiqiao Ai, Shunming Tao, Yike Cai, Jiquan Zhang, Ling Wang
Topics & Concepts
PI3K/AKT/mTOR pathwayChemistryCell growthCell cycleApoptosisIC50Cell cultureCancer researchIn vitroBiochemistryBiologyGeneticsHistone Deacetylase Inhibitors ResearchProtein Degradation and InhibitorsCancer Mechanisms and Therapy