Hypoxia-Inducible Factor Signaling in Macrophages Promotes Lymphangiogenesis in Leishmania major Infection
Anne K. Bowlin, Hayden Roys, Humphrey Wanjala, Manjunath Bettadapura, Gopinath Venugopal, Jessica M. Surma, M. Celeste Simon, Tiffany Weinkopff
Abstract
Vascular remodeling is a phenomenon seen in the cutaneous lesions formed during infection with Leishmania parasites. Within the lesion, Leishmania major infection leads to the infiltration of inflammatory cells, including macrophages, and is associated with hypoxic conditions and lymphangiogenesis in the local site.
Topics & Concepts
LymphangiogenesisBiologyAryl hydrocarbon receptor nuclear translocatorHypoxia-inducible factorsMyeloidCancer researchImmunologyVascular endothelial growth factor CLymphatic systemVascular endothelial growth factorCell biologyVascular endothelial growth factor ATranscription factorMetastasisCancerAryl hydrocarbon receptorGeneGeneticsBiochemistryVEGF receptorsResearch on Leishmaniasis StudiesLymphatic System and DiseasesEndometriosis Research and Treatment