NH125 Sensitizes Staphylococcus aureus to Cell Wall-Targeting Antibiotics through the Inhibition of the VraS Sensor Histidine Kinase
Shrijan Bhattarai, Lane Marsh, Kelsey Knight, Liaqat Ali, Antonio Gómez, Allison Sunderhaus, May H. Abdel Aziz
Abstract
in a noncompetitive manner and investigate its effect on gene expression and bacterial growth kinetics in the presence and absence of cell wall-targeting antibiotics. NH125 effectively potentiated the effects of the antibiotics on bacterial growth and altered the expression of the genes that are regulated by VraS and are involved in mounting a resistance to antibiotics.
Topics & Concepts
Histidine kinaseHistidineStaphylococcus aureusChemistryDivalentEnzymeAntibioticsKinaseMicrobiologyBiochemistryBacteriaBiologyGeneticsOrganic chemistryAntimicrobial Resistance in StaphylococcusAntibiotic Resistance in BacteriaBacterial biofilms and quorum sensing