A discrete subset of epigenetically primed human NK cells mediates antigen-specific immune responses
Victoria Stary, Ram Vinay Pandey, Johanna Strobl, Lisa Kleißl, Patrick Starlinger, David Pereyra, Wolfgang Weninger, Gottfried Fischer, Christoph Bock, Matthias Farlik, Georg Stary
Abstract
NK cells are able to bypass the KIR receptor-ligand system upon antigen-specific stimulation. Furthermore, these cells were highly migratory toward chemokine gradients expressed in epicutaneous patch test lesions as an effector site of adaptive immune responses in the skin. These results define pathways operative in human antigen-specific adaptive NK cells and provide a roadmap for harnessing this NK cell subset for specific therapeutic or prophylactic vaccine strategies.
Topics & Concepts
BiologyImmune systemImmunologyInterleukin 12EffectorAcquired immune systemCell biologyNatural killer cellCD16AntigenEpigeneticsPopulationCytotoxic T cellGeneticsGeneMedicineCD3CD8In vitroEnvironmental healthImmune Cell Function and InteractionT-cell and B-cell ImmunologyImmunotherapy and Immune Responses