RETRACTED: Co-delivery of paclitaxel and curcumin loaded solid lipid nanoparticles for improved targeting of lung cancer: In vitro and in vivo investigation
Mao Li, Gang Fang, Fatima Zahid, Raheela Saleem, Ghazala Ishrat, Zakir Ali, Muhammad Naeem, Fakhar ud Din
Abstract
tumor investigation of PAC-CUR-SLNs exhibited 12-fold reduced tumor volume and almost no change in body weight of BALB/c mice, when compared with the experimental groups including control group. The inhibition of tumor rate on day 28 was 82.7 % in the PAC-CUR-SLNs group, which was significantly higher than the pure drugs and monotherapies. It can be concluded that, encapsulating the co-loaded antitumor drugs like PAC-CUR in SLNs may help in improved targeting of the tumor with enhanced anticancer effect.
Topics & Concepts
CurcuminSolid lipid nanoparticlePaclitaxelIn vivoLung cancerPharmacologyIn vitroCancerChemistryMedicineNanotechnologyMaterials scienceOncologyInternal medicineBiochemistryBiologyDrugBiotechnologyCurcumin's Biomedical ApplicationsAdvancements in Transdermal Drug DeliveryNanoparticle-Based Drug Delivery