Antimicrobial Metabolites against Methicillin-Resistant Staphylococcus aureus from the Endophytic Fungus Neofusicoccum australe
Melissa M. Cadelis, Soeren Geese, Benedict Uy, Daniel R. Mulholland, Shara J. van de Pas, Alex Grey, Bevan Weir, Brent R. Copp, Siouxsie Wiles
Abstract
Antimicrobial bioassay-guided fractionation of the endophytic fungi Neofusicoccum australe led to the isolation of a new unsymmetrical naphthoquinone dimer, neofusnaphthoquinone B (1), along with four known natural products (2–5). Structure elucidation was conducted by nuclear magnetic resonance (NMR) spectroscopic methods, and the antimicrobial activity of all the natural products was investigated, revealing 1 to be moderately active towards methicillin-resistant Staphylococcus aureus (MRSA) with a minimum inhibitory concentration (MIC) of 16 µg/mL.
Topics & Concepts
AntimicrobialStaphylococcus aureusMicrobiologyMethicillin-resistant Staphylococcus aureusFungusMinimum inhibitory concentrationPlant use of endophytic fungi in defenseChemistryBiologyBotanyBacteriaGeneticsMicrobial Natural Products and BiosynthesisFungal Biology and ApplicationsPlant-Microbe Interactions and Immunity