Novel Bile Acid-Dependent Mechanisms of Hepatotoxicity Associated with Tyrosine Kinase Inhibitors
Chitra Saran, Louise Sundqvist, Henry Ho, Jonna Niskanen, Paavo Honkakoski, Kim L. R. Brouwer
Topics & Concepts
Bile Salt Export PumpBile acidDasatinibTauroursodeoxycholic acidPharmacologyFGF19PazopanibTyrosine kinaseToxicitySorafenibTaurocholic acidChemistryDownregulation and upregulationMedicineInternal medicineBiochemistryHepatocellular carcinomaSunitinibCancerSignal transductionReceptorTransporterUnfolded protein responseGeneEndoplasmic reticulumFibroblast growth factorDrug Transport and Resistance MechanismsDrug-Induced Hepatotoxicity and ProtectionPharmacological Effects and Toxicity Studies