Circadian Clock Control of Translation Initiation Factor eIF2α Activity Requires eIF2γ-Dependent Recruitment of Rhythmic PPP-1 Phosphatase in <i>Neurospora crassa</i>
Zhaolan Ding, Teresa M. Lamb, Ahmad Boukhris, Rachel Porter, Deborah Bell‐Pedersen
Abstract
eIF2α is phosphorylated and inactivated by CPC-3 kinase. At night, a clock-controlled phosphatase, PPP-1, dephosphorylates and activates eIF2α, leading to increased nighttime protein synthesis. Translation requires significant cellular energy; thus, partitioning translation to the night by the clock provides a mechanism to coordinate energy metabolism with protein synthesis and cellular growth.
Topics & Concepts
Neurospora crassaCircadian clockCircadian rhythmTranslation (biology)BiologyCell biologyDephosphorylationeIF2NeurosporaPhosphorylationProtein biosynthesisTranslational regulationPhosphataseMessenger RNABiochemistryGeneEndocrinologyMutantPhotosynthetic Processes and MechanismsMitochondrial Function and PathologyLight effects on plants