The Notch Pathway: A Link Between COVID-19 Pathophysiology and Its Cardiovascular Complications
Randa M. Breikaa, Brenda Lilly
Abstract
COVID-19 is associated with a large number of cardiovascular sequelae, including dysrhythmias, myocardial injury, myocarditis and thrombosis. The Notch pathway is one likely culprit leading to these complications due to its direct role in viral entry, inflammation and coagulation processes, all shown to be key parts of COVID-19 pathogenesis. This review highlights links between the pathophysiology of SARS-CoV2 and the Notch signaling pathway that serve as primary drivers of the cardiovascular complications seen in COVID-19 patients.
Topics & Concepts
CulpritPathophysiologyMedicinePathogenesisMyocarditisViral MyocarditisCoronavirus disease 2019 (COVID-19)ThrombosisInflammationCardiologyInternal medicineDiseaseMyocardial infarctionInfectious disease (medical specialty)COVID-19 Clinical Research StudiesBiomarkers in Disease MechanismsPhagocytosis and Immune Regulation