Oral administration of sodium bicarbonate can enhance the therapeutic outcome of Doxil® via neutralizing the acidic tumor microenvironment
Hidenori Ando, Ai Ikeda, Maho Tagami, Nana Cristina Amorim Matsuo, Taro Shimizu, Yu Ishima, Kiyoshi Eshima, Tatsuhiro Ishida
Topics & Concepts
Tumor microenvironmentPharmacologyChemistrySodium bicarbonateDoxorubicinSystemic administrationOral administrationCancer researchDoxorubicin HydrochlorideAngiogenesisBicarbonateMedicineIn vivoChemotherapyTumor cellsBiologyInternal medicinePhysical chemistryOrganic chemistryBiotechnologyCancer, Hypoxia, and MetabolismATP Synthase and ATPases ResearchEnzyme function and inhibition