Protein Tyrosine Phosphatase SHP2 Suppresses Host Innate Immunity against Influenza A Virus by Regulating EGFR-Mediated Signaling
Qingsen Wang, Wenliang Pan, Song Wang, Pan Chen, Hongya Ning, Shile Huang, Shih-Hsin Chiu, Ji‐Long Chen
Abstract
The results suggest that SHP2 is a key signal transducer between EGFR and ERK and plays a crucial role in suppressing host innate immunity during IAV infection. The finding enhances our understanding of influenza immune evasion and provides a new therapeutic approach to viral infection.
Topics & Concepts
BiologyInnate immune systemInfluenza A virusProtein tyrosine phosphataseDownregulation and upregulationImmunityVirologyVirusImmune systemSignal transductionImmunologyCell biologyGeneBiochemistryProtein Tyrosine Phosphatasesinterferon and immune responsesCytokine Signaling Pathways and Interactions