Modulation of TNFR 1-triggered two opposing signals for inflammation and apoptosis via RIPK 1 disruption by geldanamycin in rheumatoid arthritis
Yukihiko Saeki, Yasutaka Okita, Eri Igashira-Oguro, Chikako Udagawa, Atsuko Murata, Takashi Tanaka, Jyunji Mukai, Keiji Miyazawa, Yoshihiko Hoshida, Shiro Ohshima
Topics & Concepts
GeldanamycinProinflammatory cytokineTumor necrosis factor alphaNecroptosisApoptosisCancer researchXIAPCaspase 8Rheumatoid arthritisMedicineInflammationCell biologyPharmacologyImmunologyCaspaseProgrammed cell deathChemistryBiologyHsp90BiochemistryHeat shock proteinGeneNF-κB Signaling PathwaysCell death mechanisms and regulationImmune Response and Inflammation