Design, synthesis, and molecular docking of novel pyrazole-chalcone analogs of lonazolac as 5-LOX, iNOS and tubulin polymerization inhibitors with potential anticancer and anti-inflammatory activities
Asmaa Ahmed, Mamdouh F. A. Mohamed, Rasha M. Allam, Ayman Nafady, Shaaban K. Mohamed, Ahmed Gouda, Eman A. M. Beshr
Topics & Concepts
ChalconeChemistryHeLaCancer cellTubulinIC50MTT assayCytotoxicityPharmacologyCell cycle checkpointDocking (animal)ApoptosisCancerCell cycleBiochemistryStereochemistryIn vitroMicrotubuleBiologyCell biologyGeneticsMedicineNursingSynthesis and biological activityClick Chemistry and ApplicationsInflammatory mediators and NSAID effects