Inhibitory Circuits in the Basolateral Amygdala in Aversive Learning and Memory
Madhusoothanan B. Perumal, Pankaj Sah
Abstract
Neural circuits in the basolateral amygdala (BLA) play a pivotal role in the learning and memory formation, and processing of emotionally salient experiences, particularly aversive ones. A diverse population of GABAergic neurons present in the BLA orchestrate local circuits to mediate emotional memory functions. Targeted manipulation of GABAergic neuronal subtypes has shed light on cell-type specific functional roles in the fear learning and memory, revealing organizing principles for the operation of inhibitory circuit motifs in the BLA.
Topics & Concepts
NeuroscienceBasolateral amygdalaAmygdalaGABAergicInhibitory postsynaptic potentialBiological neural networkPsychologyNeuronal circuitsPopulationOptogeneticsMedicineEnvironmental healthMemory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeuroendocrine regulation and behavior