High prevalence and global distribution of fosfomycin resistance genes in Salmonella serovars

Abstract

Fosfomycin, an old antimicrobial agent with a broad spectrum of activity, has been reintroduced into clinical use for the treatment of patients with difficult-to-treat-infections,1 including those due to carbapenem-resistant Enterobacterales.2 However, fosfomycin-resistant bacterial strains (including Salmonella spp) have emerged and spread, potentially posing a crucial threat to public health3 as Salmonella spp are a major culprit of diarrhoeal and invasive diseases globally and fosfomycin represents an attractive treatment option.

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