Structure of Rift Valley Fever Virus RNA-Dependent RNA Polymerase
Xue Wang, Cuixia Hu, Wei Ye, Jia Wang, Xiaofei Dong, Jie Xu, Xiaorong Li, Manfeng Zhang, Hongyun Lu, Fanglin Zhang, Wei Wu, Shaodong Dai, Hongwei Wang, Zhongzhou Chen
Abstract
The zoonosis RVF virus (RVFV) is one of the most serious arbovirus threats to both human and animal health. RNA-dependent RNA polymerase (RdRp) is a multifunctional enzyme catalyzing genome replication as well as viral transcription, so the RdRp is essential for studying the virus and has multiple drug targets.
Topics & Concepts
BiologyRNA-dependent RNA polymerasePhlebovirusVirologyRNARNA polymeraseTranscription (linguistics)Viral replicationPolymeraseRNA virusViral structural proteinRNA polymerase IVirusGeneticsBunyaviridaeViral entryDNAGenePhilosophyLinguisticsViral Infections and VectorsMosquito-borne diseases and controlVector-Borne Animal Diseases