Long‐term survival outcomes of undifferentiated embryonal sarcoma of the liver: a pooled analysis of 308 patients
Zhiyong Wu, You-Zhu Wei, Zhibin Cai, Yanming Zhou
Abstract
BACKGROUND: Treatment of undifferentiated embryonal sarcoma of the liver (UESL) is a great clinical challenge due to its rarity. This study aims to examine the long-term survival of UESL patients after treatment using different therapeutic modalities. METHODS: A pooled analysis of individual data was performed on all UESL patients obtained from literature search (n = 307) and our institution (n = 1). RESULTS: The 5-year overall survival rate of the 308 patients was 65.8%, 70% for partial hepatectomy group (n = 271), 78.9% for liver transplantation group (n = 14) and 6.6% for nonsurgical treatment group (n = 23). For patients receiving partial hepatectomy, paediatric patients, radical resection and combined chemotherapy were independent predictors for improved survival. CONCLUSION: Radical hepatectomy combined chemotherapy should be considered as the preferred treatment option for USEL. Liver transplantation appears to be a reasonable alternative for unresectable disease.