A glutathione-responsive PEGylated nanogel with doxorubicin-conjugation for cancer therapy
Shufen Li, Qiang Wang, Xiao Duan, Zhen Pei, Zhipeng He, Wei Guo, Ling‐Na Han
Abstract
) groups. Meanwhile, the body weight of mice as well as the H&E and TUNEL tissue section staining of organs and tumor tissues from the mice illustrated that the nanogel could significantly prevent side effects and induce tumor cell apoptosis. Taken together, compared with free Dox, the Dox-conjugated nanogel exhibited higher therapeutic efficacy and lower side effects in normal tissues, making it a potential novel nanomedicine for cancer.
Topics & Concepts
NanogelDoxorubicinGlutathionePolyethylene glycolPEG ratioLinkerConjugated systemMaterials scienceDisulfide bondPEGylationCombinatorial chemistryPolymer chemistryChemistryDrug deliveryNanotechnologyOrganic chemistryPolymerChemotherapyBiochemistryMedicineEnzymeComputer scienceSurgeryEconomicsFinanceOperating systemNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsGraphene and Nanomaterials Applications