An Overview of Ischemia–Reperfusion Injury: Review on Oxidative Stress and Inflammatory Response
Mustafa Can Güler, Ayhan Tanyeli̇, Fazile Nur Eki̇nci̇ Akdemi̇r, Ersen Eraslan, Saime Özbek Şebin, Derya Güzel Erdoğan, Tuncer Nacar
Abstract
Ischemia–reperfusion is a common health problem leading to several health conditions. The pathophysiology of ischemia–reperfusion is quite complex. Oxidative stress and inflammatory response contribute to ischemia–reperfusion mechanisms. Various parameters like proinflammatory cytokines, reactive oxygen species, occur during ischemia–reperfusion . There are several ways to investigate these values through biochemical and histopathologic findings. Malondialdehyde, glutathione, myeloperoxidase, superoxide dismutase, interleukin 6, interleukin 1β, tumor necrosis factor alpha, caspase-3, nuclear factor-kappa β, and LC3B (microtubu le-associated protein light chain 3, LC3) can be evaluated among these indicators. Cite this article as: Can Güler M, Tanyeli A, Nur Ekinci Akdemir F, Eraslan E, Özbek Şebin S, Güzel Erdoğan D, Nacar T. An overview of ischemia– reperfusion injury: Review on oxidative stress and inflammatory response. Eurasian J Med., 2022;54(Suppl. 1), S62-S65