Integrin α4 up-regulation activates the hedgehog pathway to promote arsenic and benzo[α]pyrene co-exposure-induced cancer stem cell-like property and tumorigenesis
Jie Xie, Ping Yang, Hsuan-Pei Lin, Yunfei Li, Marco Clementino, William Fenske, Chengfeng Yang, Chunhong Wang, Zhishan Wang
Topics & Concepts
Benzo(a)pyreneChemistryCarcinogenCarcinogenesisCancer researchDownregulation and upregulationHedgehog signaling pathwayHedgehogPI3K/AKT/mTOR pathwaySignal transductionBiochemistryBiologyGeneHedgehog Signaling Pathway StudiesEpigenetics and DNA MethylationRenal and related cancers