The anti-cancer effect of betulinic acid in u937 human leukemia cells is mediated through ROS-dependent cell cycle arrest and apoptosis
Cheol Park, Jin-Woo Jeong, Min Ho Han, Hyesook Lee, Gi‐Young Kim, Soojung Jin, Jungha Park, Hyun Ju Kwon, Byung Woo Kim, Yung Hyun Choi
Abstract
-acetyl-cysteine, an ROS scavenger, markedly abolished BA-induced G2/M arrest and apoptosis, indicating that the generation of ROS plays a key role in inhibiting the proliferation of U937 cells by BA treatment. Taken together, our results provide a mechanistic rationale that BA exhibits anti-cancer properties in U937 leukemia cells through ROS-dependent induction of cell cycle arrest at G2/M phase and apoptosis.
Topics & Concepts
U937 cellReactive oxygen speciesApoptosisBetulinic acidCancer cellChemistryCell cycle checkpointCell cycleCell biologyBiochemistryBiologyCancerGeneticsNatural product bioactivities and synthesisPlant biochemistry and biosynthesisBioactive Compounds and Antitumor Agents