Discovery and Mechanism of SARS-CoV-2 Main Protease Inhibitors
Sarah Huff, Indrasena Reddy Kummetha, Shashi Kant Tiwari, Matthew B. Huante, Alex E. Clark, Shaobo Wang, William Bray, Davey M. Smith, Aaron F. Carlin, Mark Endsley, Tariq M. Rana
Abstract
inhibition that should facilitate the design of future COVID-19 treatments.
Topics & Concepts
ChemistryVero cellProteaseViral replicationCoronavirusSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Docking (animal)VirologyIC50Viral life cycleInduced pluripotent stem cellCoronavirus disease 2019 (COVID-19)PharmacologyIn vitroBiochemistryEnzymeVirusBiologyMedicineInfectious disease (medical specialty)GeneEmbryonic stem cellDiseaseNursingPathologySARS-CoV-2 and COVID-19 ResearchComputational Drug Discovery Methodsinterferon and immune responses