From irreversible to reversible covalent inhibitors: Harnessing the andrographolide scaffold for anti-inflammatory action
Quy T.N. Tran, Daniel W.S. Tan, W.S. Fred Wong, Christina L. L. Chai
Topics & Concepts
AndrographolideChemistryPotencyCovalent bondMichael reactionBiological activityIn vitroCombinatorial chemistryNatural productIn vivoStructure–activity relationshipReactivity (psychology)Drug discoveryPharmacologyChemical synthesisEnoneBiochemistryStereochemistryOrganic chemistryMedicineBiologyAlternative medicineCatalysisBiotechnologyPathologyAndrographolide Research and ApplicationsNatural Compounds in Disease TreatmentBerberine and alkaloids research