Thymoquinone Induces Nrf2 Mediated Adaptive Homeostasis: Implication for Mercuric Chloride-Induced Nephrotoxicity
Shakila Sabir, Uzma Saleem, Muhammad Sajid Hamid Akash, Muhammad Qasim, Zunera Chauhdary
Abstract
BACKGROUND: the primary function of the kidney is to eliminate metabolic waste products and xenobiotics from the circulation. During this process, the kidney may become vulnerable to toxicity. OBJECTIVE: )-induced nephrotoxicity through estimation of various proteins involved in natural defense mechanisms. MATERIAL AND METHODS: administration. The protective effect of TQ was evaluated from renal and liver function biomarkers, urine examination, glomerulus filtration rate (GFR), histopathological features, oxidative stress biomarkers, Hsp-70, apoptosis biomarkers, and gene expression. RESULTS: -induced cell death and decreased % DNA fragmentation. TQ increased the expression of protective proteins metallothionein I and II and reduced the expression of kidney injury molecule-1 (Kim-1). CONCLUSION: -induced nephrotoxicity through modifications of various constitutive and inducible protein and enzyme levels in renal tissues.