Prevalence and prognostic value of cardiac troponin in elderly patients hospitalized for COVID-19.
Vincenzo De Marzo, Antonio Di Biagio, Roberta Della Bona, Antonio Vena, Eleonora Arboscello, Harusha Emirjona, Sara Mora, Mauro Giacomini, Giorgio Da Rin, Paolo Pelosi, Matteo Bassetti, Pietro Ameri, Italo Porto, Gecovid Study Group
Abstract
BACKGROUND: Increases in cardiac troponin (cTn) in coronavirus disease 2019 (COVID-19) have been associated with worse prognosis. Nonetheless, data about the significance of cTn in elderly subjects with COVID-19 are lacking. METHODS: From a registry of consecutive patients with COVID-19 admitted to a hub hospital in Italy from 25/02/2020 to 03/07/2020, we selected those ≥ 60 year-old and with cTnI measured within three days from the molecular diagnosis of SARS-CoV-2 infection. When available, a second cTnI value within 48 h was also extracted. The relationship between increased cTnI and all-cause in-hospital mortality was evaluated by a Cox regression model and restricted cubic spline functions with three knots. RESULTS: = 0.265). CONCLUSIONS: In elderly COVID-19 patients, an initial increase in cTn is common and predicts a higher risk of death. Serial cTn testing may not confer additional prognostic information.