Etching Triangular Silver Nanoparticles by Self-generated Hydrogen Peroxide to Initiate the Response of an Electrochemiluminescence Sensing Platform
Jingwei Xue, Yue Jia, Lei Yang, Jinhui Feng, Dan Wu, Xiang Ren, Yu Du, Huangxian Ju, Qin Wei
Abstract
and the ECL detection procedure are independent. Therefore, the proposed system can avert the impact of complex biological samples effectively, and the ECL efficiency of the Ru(II) complex can be readily utilized. On this basis, a biosensor is explored for the primary diagnosis of squamous cell carcinoma by detecting the biomarker named after cytokeratin fragment 19 (CYFRA21-1), from which an excellent linearity from 0.1 pg/mL to 50 ng/mL is achieved with a detection limit of 0.058 pg/mL. All of these results confirmed that this strategy can be a promising candidate for fabricating an ECL-based biosensor.
Topics & Concepts
ChemistryElectrochemiluminescenceRutheniumDetection limitHydrogen peroxideCombinatorial chemistryBiosensorPhotochemistryNanotechnologyChromatographyCatalysisOrganic chemistryMaterials scienceBiochemistryAdvanced biosensing and bioanalysis techniquesBiosensors and Analytical DetectionElectrochemical Analysis and Applications