Spirodesertols A and B, two highly modified spirocyclic diterpenoids with an unprecedented 6-isopropyl-3<i>H</i>-spiro[benzofuran-2,1′-cyclohexane] motif from <i>Salvia deserta</i>
Guijuan Zheng, Abdukriem Kadir, Xiaofeng Zheng, Pengfei Jin, Junjun Liu, Maitinuer Maiwulanjiang, Guangmin Yao, Haji Akber Aisa
Abstract
Two highly modified spirocyclic diterpenoids with an unprecedented 6-isopropyl-3<italic>H</italic>-spiro[benzofuran-2,1′-cyclohexane] motif and four new icetexane diterpenoids were isolated from <italic>Salvia deserta</italic>. <bold>1</bold> showed more potent cytotoxicity than <italic>cis</italic>-platin.
Topics & Concepts
ChemistryBenzofuranStereochemistryCyclohexaneIsopropylSalviaMedicinal chemistryOrganic chemistryTraditional medicineMedicineTraditional Chinese Medicine AnalysisNatural product bioactivities and synthesisPhytochemistry and Biological Activities