Synthesis of Thiocarbamoyl Fluorides and Isothiocyanates Using Amines with CF<sub>3</sub>SO<sub>2</sub>Cl
Jingjing Wei, Shuaishuai Liang, Lvqi Jiang, Wenbin Yi
Abstract
A practical and efficient method to synthesize thiocarbamyl fluorides and isothiocyanates from amines with trifluoromethanesulfonyl chloride was developed. In the presence of the reducing agent triphenylphosphine and sodium iodide, thiocarbamyl fluorides and isothiocyanates were synthesized from secondary/primary amine in moderate to excellent yields, respectively. A broad scope of substrates and good functional group compatibility were observed.
Topics & Concepts
ChemistryAmine gas treatingIodideTriphenylphosphinePrimary (astronomy)ChlorideSodiumCyclic aminesOrganic chemistryCombinatorial chemistryInorganic chemistryCatalysisAstronomyPhysicsFluorine in Organic ChemistrySulfur-Based Synthesis TechniquesSynthesis and Catalytic Reactions