Stimulus-independent and stimulus-dependent neural networks underpin placebo analgesia responsiveness in humans
Lewis Crawford, Noemi Meylakh, Paul M. Macey, Vaughan G. Macefield, Kevin A. Keay, Luke A. Henderson
Abstract
The neural circuits that regulate placebo analgesia responsivity are unknown, although engagement of brainstem pain modulatory regions is likely critical. Here we show in 47 participants that differences are present in neural circuit connectivity's in placebo responders versus non-responders. We distinguish stimulus-independent and stimulus-dependent neural networks that display altered connections between the hypothalamus, anterior cingulate cortex and midbrain periaqueductal gray matter. This dual regulatory system underpins an individual's ability to mount placebo analgesia.
Topics & Concepts
Stimulus (psychology)NeurosciencePeriaqueductal grayBrainstemAnterior cingulate cortexPlaceboMidbrainPsychologyInsular cortexNeural correlates of consciousnessBiological neural networkMedicineCentral nervous systemCognitive psychologyCognitionPathologyAlternative medicinePain Management and Placebo EffectPain Mechanisms and TreatmentsParanormal Experiences and Beliefs