Catalytic (3 + 2) umpolung annulations of α-thioacyl carbenes with aryl isothiocyanates
Ziyang Dong, Mengyao Ma, Jiaxi Xu, Zhanhui Yang
Abstract
As masked S-electrophilic thia-1,3-dipoles, 1,2,3-thiadiazoles undergo denitrogenative (3 + 2) umpolung transannulations with aryl isothiocyanates, regio- and stereoselectively.
Topics & Concepts
UmpolungChemistryArylElectrophileRegioselectivityIntramolecular forceOrganocatalysisCatalysisStereoselectivityMedicinal chemistryHydroaminationStereochemistryNucleophileCombinatorial chemistryOrganic chemistryEnantioselective synthesisAlkylCyclopropane Reaction MechanismsN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic C–H Functionalization Methods