Visible‐Light‐Promoted Electron Donor‐Acceptor Complex Enabled Decarboxylative Alkylation of Quinoxalin‐2(1<i>H</i>)‐ones and <i>N</i>‐Hydroxyphthalimide Esters with Na<sub>2</sub>S as a Catalytic Donor
Hai‐Yang Song, Zhuo‐Tao Zhang, Hong‐Yu Tan, Yuhan Lu, Tianbao Yang, Jin‐Yang Chen, Hong‐Tao Ji, Wei‐Min He
Abstract
Abstract We developed a novel and efficient method for the synthesis of various 3‐alkylated quinoxalin‐2(1 H )‐ones (32 examples, 70%–96% yields) through electron donor‐acceptor complex enabled alkylation of quinoxalin‐2(1 H )‐ones with N ‐ hydroxyphthalimide esters as the alkyl source and Na 2 S as the catalytic electron donor under external photocatalyst‐, oxidant‐ and additive‐free conditions.
Topics & Concepts
ChemistryAlkylationElectron acceptorElectron donorAlkylCatalysisAcceptorPhotocatalysisMedicinal chemistryPhotochemistryCombinatorial chemistryStereochemistryOrganic chemistryCondensed matter physicsPhysicsSynthesis and Biological EvaluationRadical Photochemical ReactionsOxidative Organic Chemistry Reactions