Correction of sensor crosstalk error in Exhalyzer D multiple-breath washout device significantly impacts outcomes in children with cystic fibrosis
Florian Wyler, Marc‐Alexander Oestreich, Bettina Frauchiger, Kathryn Ramsey, Philipp Latzin
Abstract
We investigated the sensor accuracy of a prominent nitrogen multiple-breath washout (N 2 MBW) device (Eco Medics AG, Duernten, Switzerland) as a possible cause of lack of comparability between outcomes of different MBW devices and methods. We identified an error in the nitrogen concentration calculation of this device, which results in a 10%–15% overestimation of primary outcomes, functional residual capacity, and lung clearance index. It also leads to a significant overestimation of nitrogen back-diffusion into the lungs.
Topics & Concepts
Cystic fibrosisCrosstalkWashoutMedicineInternal medicineCardiologyPhysicsOpticsCystic Fibrosis Research AdvancesWireless Body Area NetworksMobile Health and mHealth Applications