Gut dysbiosis contributes to amyloid pathology, associated with C/EBPβ/AEP signaling activation in Alzheimer’s disease mouse model
Chun Chen, Eun Hee Ahn, Seong Su Kang, Xia Liu, Ashfaqul Alam, Keqiang Ye
Abstract
antagonizes the C/EBPβ/AEP axis, mitigating gut leakage and oxidative stress. Our findings support the hypothesis that C/EBPβ/AEP signaling is activated by gut dysbiosis, implicated in AD pathologies in the gut.
Topics & Concepts
DysbiosisSignal transductionGut floraGut–brain axisGenetically modified mouseAmyloid (mycology)BiologyMedicineCell biologyImmunologyTransgenePathologyBiochemistryGeneGut microbiota and healthAlzheimer's disease research and treatmentsProbiotics and Fermented Foods