Sex Differences in Neuromuscular Aging: The Role of Sex Hormones
Jessica Piasecki, Jakob Škarabot, Pádraig Spillane, Mathew Piasecki, Paul Ansdell
Abstract
Males and females experience different trajectories of neuromuscular function across the lifespan, with females demonstrating accelerated deconditioning in later life. We hypothesize that the menopause is a critical period in the female lifespan, during which the dramatic reduction in sex hormone concentrations negatively impacts synaptic input to the motoneuron pool, as well as motor unit discharge properties.
Topics & Concepts
HormoneDeconditioningHealthy agingMenopauseFacilitationPsychologyBiologyEndocrinologyInternal medicineMedicinePhysiologyNeuroscienceGerontologyMuscle Physiology and DisordersMuscle activation and electromyography studiesTranscranial Magnetic Stimulation Studies