Channeling Nicotinamide Phosphoribosyltransferase (NAMPT) to Address Life and Death
Velma Ganga Reddy, Isabella S. Krider, Erick T. M. Alves, Jenna M. Courey, Megan S. Laham, Gregory R. J. Thatcher
Abstract
boosters". NAMPT positive allosteric modulators (N-PAMs) and boosters may increase enzyme activity by relieving substrate/product inhibition. Binding to a "rear channel" extending from the NAMPT active site is key for inhibitors, boosters, and N-PAMs. A deeper understanding may fulfill the potential of NAMPT ligands to regulate cellular life and death.
Topics & Concepts
Nicotinamide phosphoribosyltransferaseNAD+ kinaseChemistryAllosteric regulationNicotinamide adenine dinucleotideNicotinamideEnzymeProgrammed cell deathBiochemistryNicotinamide mononucleotideCancer researchPharmacologyBiologyApoptosisSirtuins and Resveratrol in MedicinePARP inhibition in cancer therapyCalcium signaling and nucleotide metabolism