Asymmetric organocatalytic sulfenylation for the construction of a diheteroatom-bearing tetrasubstituted carbon centre
Qingfa Tan, Qianping Chen, Zitong Zhu, Xiaohua Liu
Abstract
Catalytic enantioselective sulfenylation to construct diheteroatom-bearing carbon centres was achieved by employing chiral guanidine organocatalysts. This protocol provided a facile route towards the synthesis of α-fluoro-α-sulfenyl-β-ketoamides, azlactone adducts and α-sulfur-substituted amino acid derivatives in high yields with good to excellent enantioselectivities. A possible working mode was proposed to elucidate the chiral control of the process.
Topics & Concepts
Enantioselective synthesisSulfurAdductCarbon fibersCatalysisChemistryOrganocatalysisGuanidineCombinatorial chemistryOrganic chemistryComputer scienceAlgorithmComposite numberSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions