Dual-responsive PEG–lipid polyester nanoparticles for siRNA and vaccine delivery elicit anti-cancer immune responses by modulating tumor microenvironment
Zixu Liu, Linxuan Zhao, Yupeng Feng, Qingqing Wang, Nan Dong, Yu Zhang, Tian Yin, Haibing He, Xing Tang, Jingxin Gou, Yang Li
Abstract
Dual-responsive PEG-lipid polyester nanoparticles (PEG BR647-NPs) were employed as a vaccine and STAT3 siRNA carrier for tumor-targeted delivery to modulate the tumor microenvironment.
Topics & Concepts
Tumor microenvironmentCancer researchCancer immunotherapyImmunotherapyImmune systemChemistryTumor antigenAntigenAntigen presentationImmunologyT cellBiologyImmunotherapy and Immune ResponsesRNA Interference and Gene DeliveryCAR-T cell therapy research