Inhibition of CRISPR-Cas12a trans-cleavage by lead (II)-induced G-quadruplex and its analytical application
Ying Yu, Wenhui Li, Xinzhe Gu, Xiaojun Yang, Yiyi Han, Yingqing Ma, Zhengwu Wang, Juan Zhang
Topics & Concepts
CRISPRCleavage (geology)Förster resonance energy transferG-quadruplexChemistryDetection limitDNABiophysicsStereochemistryCombinatorial chemistryFluorescenceBiologyGeneBiochemistryChromatographyPhysicsPaleontologyQuantum mechanicsFracture (geology)Advanced biosensing and bioanalysis techniquesCRISPR and Genetic EngineeringDNA and Nucleic Acid Chemistry